منابع مشابه
Mammary gland neoplasia.
Determining how findings of chemically induced carcinogenic effects in rodents can properly be interpreted for human health poses a continuing challenge to the risk assessment community. One approach begins by comparing and contrasting carcinogenic process in rodents and humans, identifying biologically significant similarities and differences and gaps in scientific knowledge and understanding....
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Study on the role of microRNAs (miRs) as regulators of gene expression through posttranscriptional gene silencing is currently gaining much interest,due to their wide involvement in different physiological processes. Understanding mammary gland development, lactation, and neoplasia in relation to miRs is essential. miR expression profiling of the mammary gland from different species in various ...
متن کاملMammary gland neoplasia in long-term rodent studies.
Breast cancer, the most frequent spontaneous malignancy diagnosed in women in the western world, is continuously increasing in incidence in industrialized nations. Although breast cancer develops in women as the result of a combination of external and endogenous factors such as exposure to ionizing radiation, diet, socioeconomic status, and endocrinologic, familial, or genetic factors, no speci...
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To characterize the role of BRCA1 in mammary gland development and tumor suppression, a transgenic mouse model of BRCA1 overexpression was developed. Using the mouse mammary tumor virus (MMTV) promoter/enhancer, transgenic mice expressing human BRCA1 or select mutant controls were generated. Transgenic animals examined during adolescence were shown to express the human transgene in their mammar...
متن کاملΔn89β-Catenin Induces Precocious Development, Differentiation, and Neoplasia in Mammary Gland
To investigate the role of beta-catenin in mammary gland development and neoplasia, we expressed a stabilized, transcriptionally active form of beta-catenin lacking the NH(2)-terminal 89 amino acids (Delta N 89 beta-catenin) under the control of the mouse mammary tumor virus long terminal repeat. Our results show that Delta N 89 beta-catenin induces precocious lobuloalveolar development and dif...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1996
ISSN: 0091-6765
DOI: 10.2307/3433131